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Pharmaceutical Cleaning Validation Checklist

Ensure pharmaceutical product purity & compliance. This Cleaning Validation Checklist streamlines your cleaning process, minimizes contamination risk, and simplifies your documentation - a must-have for any pharma facility.

This Template was installed 4 times.

Scope Definition & Planning

1 of 10

Defines the equipment, cleaning agents, and acceptance criteria for validation.

Objective of Cleaning Validation

Equipment ID/Code

Product(s) Processed on Equipment

Brief Description of Equipment

Date of Scope Definition

Justification for Cleaning Validation Approach

Cleaning Agent Selection & Compatibility

2 of 10

Ensures selected cleaning agents are effective and compatible with equipment materials.

Rationale for Cleaning Agent Selection

Cleaning Agent Type

Cleaning Agent Name

Cleaning Agent Concentration (%)

pH of Cleaning Agent

Material Compatibility Assessment (Equipment Materials)

Compatibility Result

Cleaning Procedure Development

3 of 10

Details the step-by-step cleaning process, including contact times, temperatures, and rinsing steps.

Detailed Cleaning Procedure Steps

Cleaning Agent Concentration (%)

Rinse Water Temperature (°C)

Rinse Time (minutes)

Cleaning Agent Type

Contact Time (minutes)

Water Source

Specific Equipment Considerations

Equipment Sampling & Monitoring

4 of 10

Outlines the locations and methods for sampling equipment surfaces during cleaning validation runs.

Sampling Point 1: Equipment Surface Location

Number of Swab Samples Collected

Rinse Volume (mL)

Sampling Date

Sampling Time

Swab Material Type

Sampling Location Photo (Optional)

Residue Limit Determination

5 of 10

Defines the acceptable residue limits for cleaning agents and product carryover.

Residue Limit for Cleaning Agent 1 (ppm)

Residue Limit for Product Carryover (ppm)

Justification for Residue Limit Selection

Detailed Explanation of Limit Rationale

Supporting Documentation (e.g., Toxicological Report)

Date Limit Established

Analytical Method Validation

6 of 10

Verifies the analytical methods used to detect and quantify residues are fit for purpose.

Method Description

Limit of Detection (LOD)

Limit of Quantitation (LOQ)

Linearity (R-squared)

Interference Study - Substances Tested

Accuracy - Recovery %

Validation Completion Date

Analyst Signature

Cleaning Validation Runs

7 of 10

Documents the execution of cleaning validation runs and the recorded data.

Run Date

Start Time

Batch Number (if applicable)

Run Number

Equipment State Prior to Cleaning (e.g., product residue)

Cleaning Procedure Followed

Deviations from Standard Procedure (if any)

Cleaning Logs/Checklists

Operator Signature

Data Analysis & Evaluation

8 of 10

Analyzes the collected data and determines if acceptance criteria have been met.

Residue Limit for Cleaning Agent A (ppm)

Residue Concentration Found (Cleaning Run 1) (ppm)

Residue Concentration Found (Cleaning Run 2) (ppm)

Average Residue Concentration (ppm)

Acceptance Criteria Met?

Justification for Acceptance/Rejection

Date of Data Analysis Completion

Analyst Signature

Documentation & Reporting

9 of 10

Details the creation and review of the cleaning validation report.

Validation Protocol Summary

Validation Protocol Document

Cleaning Validation Report

Report Completion Date

Report Reviewer Signature

Report Approver Signature

Deviations & Corrective Actions (if applicable)

Change Control & Periodic Review

10 of 10

Describes the process for managing changes and reviewing the cleaning validation periodically.

Last Review Date

Summary of Review Findings

Review Outcome

Reason for Change (if applicable)

Revision Number

Reviewer Signature

Next Review Date

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