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Pharmaceutical Stability Program Checklist

Ensure your pharmaceutical products remain potent and safe through every stage. Our Pharmaceutical Stability Program Checklist streamlines your validation process, minimizes risk, and helps you maintain regulatory compliance. Download now and strengthen your stability testing protocols!

This Template was installed 4 times.

Program Setup & Documentation

1 of 8

Covers initial program design, SOPs, and documentation control.

Program Scope and Objectives

Program SOP (Standard Operating Procedure)

Regulatory Framework Compliance (e.g., ICH, FDA)

Program Implementation Date

Document Control Number

Responsibilities and Roles Defined

Program Owner Approval

Protocol Development

2 of 8

Focuses on establishing stability testing protocols, including test conditions, acceptance criteria, and timeline.

Rationale for Selected Storage Conditions

Container Closure System

Number of Replicates per Batch

Start Date of Stability Study

Time Points for Testing (Months)

Parameters to be Tested

Acceptance Criteria for Assay

Sample Selection & Handling

3 of 8

Ensures appropriate sample selection, storage, and preparation for stability studies.

Batch Number

Number of Samples Selected

Packaging Configuration

Sample Collection Date

Storage Condition Assignment

Sample Labeling Details

Sample Storage Location

Testing & Data Analysis

4 of 8

Covers analytical testing procedures, data analysis methods, and statistical evaluation.

Batch Number

Testing Start Date

Testing Start Time

Temperature (°C)

Humidity (%)

pH Value

Assay Result (%)

Impurity A (ppm)

Analytical Method

Trending & Reporting

5 of 8

Focuses on trend analysis, report generation, and data interpretation for stability assessment.

Batch Size Analyzed

Report Generation Date

Summary of Trending Observations

Overall Stability Status (Based on Trending)

Number of Batches Included in Trend Analysis

Justification for Stability Status

Next Review Date of Trending Data

Deviation Management & CAPA

6 of 8

Addresses deviations from stability protocols and implementation of corrective and preventative actions.

Deviation Number

Deviation Date

Description of Deviation

Deviation Severity

Root Cause Analysis

Corrective Action Plan

Corrective Action Completion Date

CAPA Approval Signature

Related Documents/Records

Periodic Review & Updates

7 of 8

Covers regular program reviews and updates to ensure ongoing effectiveness and compliance.

Last Review Date

Summary of Review Findings

Areas Requiring Updates?

Rationale for Changes

Next Review Cycle Length (Months)

Impact Assessment?

Reviewer Signature

Archiving & Data Retention

8 of 8

Focuses on secure archiving of stability data and adherence to retention time requirements.

Date of Data Archiving

Summary of Archiving Process

Number of Files Archived

Archiving Confirmation Document

Archiving Location

Retention Period (Years)

Description of Security Measures for Archive

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